TY  - JOUR
T1  - CHlorpropamide in the management of diabetes
AU  - SUGAR SN, THOMAS LJ, EUGENIO TM
Y1  - 1959/09/01
N1  - 10.1001/archinte.1959.00270090014003
JO  - A.M.A. Archives of Internal Medicine
SP  - 360
EP  - 364
VL  - 104
IS  - 3
N2  - Chlorpropamide is a new oral antidiabetic agent. Its chemical name is N-propyl-N'-(p-chloro-benzenesulfonyl)urea. The structural formula (Fig. 1) is similar to other sulfonamide derivatives which have been observed to have a blood-sugar-lowering effect.Schneider et al.,1 in a thorough pharmacological study of more than two years' duration, found chlorpropamide to be an effective, orally active hypoglycemic agent. In the rhesus monkey, this compound was found to be considerably more potent than tolbutamide and, in addition, the duration of the hypoglycemic effect was more prolonged.The purpose of the investigation reported here was to confirm the antidiabetic properties of chlorpropamide in the human, to study its therapeutic effectiveness, and to disclose the presence or absence of significant side-effects. In particular we wished to observe the effectiveness of chlorpropamide in those patients who were unresponsive to tolbutamide.Method of Study 
    Diabetic patients who were taking insulin, those inadequately controlled with tolbutamide, and an
SN  - 0888-2479
M3  - doi: 10.1001/archinte.1959.00270090014003
UR  - http://dx.doi.org/10.1001/archinte.1959.00270090014003
ER  -