TY  - JOUR
T1  - REctal cortisol in the therapy of ulcerative colitis
AU  - SCHWARTZ RD, BRODOFF M, COHN GL, SPIRO HM
Y1  - 1959/08/01
N1  - 10.1001/archinte.1959.00270080086011
JO  - A.M.A. Archives of Internal Medicine
SP  - 260
EP  - 263
VL  - 104
IS  - 2
N2  - The successful use of topical steroid therapy in diseases of the eye, skin, and joints has led to an evaluation of the effect of cortisol enemas in idiopathic ulcerative colitis. Observations from this laboratory have implied negligible absorption of cortisone from the rectum in ulcerative colitis. and so a relative absence of side-effects was to be anticipated.1 Truelove and others have reported encouraging results with rectal hydrocortisone in ulcerative colitis.2,3 This report represents an attempt to define the type of patient in whom such therapy might be most helpful.Methods 
    All 16 patients studied had the diagnosis of ulcerative colitis confirmed by sigmoidoscopy and x-ray examination at either the Grace-New Haven Community Hospital or the West Haven Veterans Administration Hospital. Stool examinations were performed to exclude amebiasis, bacillary dysentery, and other causes of diarrhea; many patients had received antiamebic therapy on an empirical basis. Table 1 illustrates an
SN  - 0888-2479
M3  - doi: 10.1001/archinte.1959.00270080086011
UR  - http://dx.doi.org/10.1001/archinte.1959.00270080086011
ER  -