TY  - JOUR
T1  - THe nephropathies of sickle-cell disease
AU  - BERMAN LB, TUBLIN II
Y1  - 1959/04/01
N1  - 10.1001/archinte.1959.00270040088011
JO  - A.M.A. Archives of Internal Medicine
SP  - 602
EP  - 606
VL  - 103
IS  - 4
N2  - Many of the complications of sickle-cell anemia have been well described and may be readily diagnosed, e. g., the pulmonary and cardiac manifestations.1,2 In contrast, the functional and morphological renal changes associated with hemoglobin S have received little intensive study until the past few years. Margolies, in a clinical and pathologic review of the subject in 1951, mentioned albuminuria, hematuria, cylindruria, frequent urinary infections, fixed specific gravities, uremia and renal thromboses, and infarctions as complications of sicklecell disease and trait.3 The nephropathies thus far described in detail include gross hematuria,4 hyposthenuria,5 fat embolism,6 and the nephrotic syndrome.7The referral of a patient with homozygous hemoglobin S and massive proteinuria provided the opportunity to observe many of these renal defects in the same subject and to study their response to corticotropin (ACTH).Report of Case 
    The patient was a 9-year-old Negro boy with eight hospital admissions preceding the present one.
SN  - 0888-2479
M3  - doi: 10.1001/archinte.1959.00270040088011
UR  - http://dx.doi.org/10.1001/archinte.1959.00270040088011
ER  -