TY  - JOUR
T1  - IRon overload (hemosiderosis) aggravated by blood transfusions
AU  - MUIRHEAD EE, CRASS GG, JONES FF, HILL JM
Y1  - 1949/05/01
N1  - 10.1001/archinte.1949.00220340002001
JO  - Archives of Internal Medicine
SP  - 477
EP  - 501
VL  - 83
IS  - 5
N2  - TWO TYPES of excessive iron deposits in the body are usually distinguished. The widespread iron deposition associated with prolonged hemolysis or following the repeated experimental injection of hemoglobin solution intravenously has been designated as hemosiderosis. The term hemochromatosis has been reserved for a special entity in which the most common features have been widespread iron deposition (hemosiderin pigment); hemofuscin deposits; increased copper content of tissues; cirrhosis and hypogonadism; pancreatic damages ("pancreatic cirrhosis") and diabetes mellitus, and skin pigmentation. These features of hemochromatosis have varied in their intensity and also in the frequency of their combination.With the advent of blood banks and the greater confidence in blood transfusion therapy, larger volumes of blood are being administered. Under special conditions it is possible for prolonged transfusion therapy to be associated with a prominent iron overload of various tissues. In certain organs this metallic excess is associated with parenchymatous damage.The
SN  - 0730-188X
M3  - doi: 10.1001/archinte.1949.00220340002001
UR  - http://dx.doi.org/10.1001/archinte.1949.00220340002001
ER  -