TY - JOUR T1 - THe amino-acid content of the blood in health and in disease AU - SCHMIDT EG Y1 - 1929/09/01 N1 - 10.1001/archinte.1929.00140030050005 JO - Archives of Internal Medicine SP - 351 EP - 361 VL - 44 IS - 3 N2 - Among the numerous constituents of the blood stream few are more closely related to many of the fundamental processes of life than the amino-acids. Yet it was only within comparatively recent times (1913) that crystalline amino-acids1 were actually isolated from the blood stream, and considerable confusion still seems to exist in regard to the amount of amino-acid nitrogen in normal and pathologic blood. Thus in a recent text on biochemistry2 the statement is found that "in diabetes mellitus there is an accumulation of amino-acids in the blood and a corresponding increased excretion into the urine. Again in nephritis there is an accumulation of amino-acids in the blood." On another page of the same book one finds the statement that "amino-nitrogen rarely rises in the blood. Even during severe nephritis there is no characteristic increase in amino-nitrogen." In a recent book on blood chemistry,3 the author said that "a definite rise SN - 0730-188X M3 - doi: 10.1001/archinte.1929.00140030050005 UR - http://dx.doi.org/10.1001/archinte.1929.00140030050005 ER -