TY  - JOUR
T1  - THe effect of synthalin on the respiratory quotient of the diabetic patient
AU  - KARR WG, SCHUMANN CC, PETTY OH
Y1  - 1929/03/01
N1  - 10.1001/archinte.1929.00130260087008
JO  - Archives of Internal Medicine
SP  - 384
EP  - 392
VL  - 43
IS  - 3
N2  - In 1926, Frank, Nothmann and Wagner1 isolated a guanidine derivative, a diguanidyl decamethylene, which they called "Synthalin." This was reported to be effective in reducing blood sugar when taken by mouth and was suggested as a substitute for insulin in the treatment of diabetes. Numerous publications have appeared, especially in Europe, concerning its use in diabetes and the possible mechanism of its action. A supply of synthalin 2 was obtained for therapeutic trial on diabetic patients. During the course of this investigation, a study was made of the respiratory quotients after a meal of dextrose. It is believed that any drug reputed to have an insulin-like action must manifest itself by an increased oxidation of carbohydrate in the diabetic organism. Blatherwick, Sahyun and Hill3 stated that synthalin may possibly produce a hypoglycemia by an insulin-like action or by interfering with normal glyconeogenesis because of injury to the liver. The present
SN  - 0730-188X
M3  - doi: 10.1001/archinte.1929.00130260087008
UR  - http://dx.doi.org/10.1001/archinte.1929.00130260087008
ER  -