TY - JOUR T1 - SPontaneous reports of ticlopidine-associated thrombotic thrombocytopenic purpura from 2 italian regions AU - Venegoni M, Conforti A, Cocci A, Leone R Y1 - 1999/10/11 N1 - JO - Archives of Internal Medicine SP - 2227 EP - 2227 VL - 159 IS - 18 N2 - Chen and colleagues1 recently reviewed 10 published case reports and described 3 new cases of ticlopidine-associated thrombotic thrombocytopenic purpura (TTP). In this communication we document the spontaneous reports of adverse drug reactions associated with ticlopidine, focusing attention on TTP, by analysis of a regional database of all the spontaneous reports sent in by physicians from the Italian Veneto and Lombardy regions. These 2 regions (13.7 million inhabitants) are the principal contributors to the Italian spontaneous reporting system (about 50% of all Italian reports), and their 1998 annual reporting rate was 202 per million inhabitants. SN - 0003-9926 M3 - doi: UR - http://dx.doi.org/ ER -