TY  - JOUR
T1  - Herbal medicinals: Selected clinical considerations, focusing on known or potential drug-herb interactions
AU  - Miller LG
Y1  - 1999/09/13
N1  - 
JO  - Archives of Internal Medicine
SP  - 1954
EP  - 1954
VL  - 159
IS  - 16
N2  - 
Rosenblatt and Mindel1 reported spontaneous hyphema in a 70-year-old man 1 week after he began ingesting Ginkgo biloba (40 mg twice daily). The patient had taken aspirin (325 mg/d) for 3 years without incident; hence, the authors felt that a temporal relationship strongly implicated ginkgo. I agree. Rowin and Lewis2 have also reported spontaneous bilateral subdural hematomas associated with long-term G biloba use. They acknowledged that their patient had taken acetaminophen and had a very brief trial of ergotamine/caffeine tablets. However, given the lack of a temporal relationship and the fact that acetaminophen, ergotamine, and caffeine have not been shown to be associated with subdural hematomas, Rowin and Lewis implicated G biloba. Furthermore, the patient's bleeding time improved following discontinuation of G biloba. Again, I agree with their conclusions. Yet another report was recently published describing a 61-year-old man who developed subarachnoid hemorrhage after ingesting G biloba (40 mg 3 or 4 times daily).3 He was not taking any other medications.

SN  - 0003-9926
M3  - doi: 
UR  - http://dx.doi.org/
ER  -