TY - JOUR T1 - Herbal medicinals: Selected clinical considerations, focusing on known or potential drug-herb interactions AU - Fugh-Berman A Y1 - 1999/09/13 N1 - JO - Archives of Internal Medicine SP - 1954 EP - 1954 VL - 159 IS - 16 N2 - The unreferenced statement that ginkgo should be avoided in patients with epilepsy is not substantiated. The statement that ginkgo toxin is found in both leaf and seed is true but misleading. Ginkgo seeds, which are eaten on special occasions in Asia, contain 4‘-O-methylpyridoxine, an anti–vitamin B6 neurotoxin. Boiling inactivates 99% of this toxin. However, during food shortages in China and Japan, overconsumption of ginkgo seeds resulted in a syndrome called gin-nan sitotoxism, with a 27% mortality rate.2 SN - 0003-9926 M3 - doi: UR - http://dx.doi.org/ ER -