TY  - JOUR
T1  - LAck of cardiovascular disease among old order amish with familial defective apolipoprotein b
AU  - Ahmad Z, Garg A
Y1  - 2011/06/13
N1  - 10.1001/archinternmed.2011.238
JO  - Archives of Internal Medicine
SP  - 1039
EP  - 1040
VL  - 171
IS  - 11
N2  - 
Surprisingly, a self-reported history of cardiovascular disease (CVD) was not different among individuals with RR, RQ, and QQ genotypes despite extremely low frequency of lipid-lowering medication use. Especially striking is the lack of increased prevalence of historical CVD in the stage 2 participants who were older, with a mean age of 57 to 59 years. We wonder if the study sample may be biased because some affected individuals harboring R3500Q variants may have developed CVD earlier in life and may have died suddenly prior to reaching their 40s (mean age in stage 1 participants). Was information about family history of premature CVD or sudden death collected? We would expect that individuals with heterozygous or homozygous R3500Q variant should report more cardiovascular events among their relatives than individuals not harboring the mutation. Alternatively, is it possible that R3500Q mutation in Old Order Amish despite increasing LDL-C levels and coronary artery calcium scores on electron beam computed tomography does not increase cardiovascular events?

SN  - 0003-9926
M3  - doi: 10.1001/archinternmed.2011.238
UR  - http://dx.doi.org/10.1001/archinternmed.2011.238
ER  -