TY  - JOUR
T1  - HArd-stops for drug interactions—reply
AU  - Strom BL, Schinnar R, Aberra F, Bilker W, Hennessy S, Leonard CE
Y1  - 2011/04/11
N1  - 10.1001/archinternmed.2011.110
JO  - Archives of Internal Medicine
SP  - 702
EP  - 710
VL  - 171
IS  - 7
N2  - 
Dr Horn is indeed correct that most of the alerts in our study were triggered by warfarin being prescribed to patients who already were receiving trimethoprim-sulfamethoxazole. Some of this was due to warfarin being prescribed 3 times more commonly than trimethoprim-sulfamethoxazole, as noted in our article.1 Dr Horn points out that dose titration of the warfarin might have allowed it to be used safely in patients already receiving trimethoprim-sulfamethoxazole. However, such patients might then be at risk of underanticoagulation when stopping therapy with trimethoprim-sulfamethoxazole, in most cases after being discharged from the hospital.

SN  - 0003-9926
M3  - doi: 10.1001/archinternmed.2011.110
UR  - http://dx.doi.org/10.1001/archinternmed.2011.110
ER  -