TY  - JOUR
T1  - HArd-stops for drug interactions
AU  - Horn JR
Y1  - 2011/04/11
N1  - 10.1001/archinternmed.2011.109
JO  - Archives of Internal Medicine
SP  - 702
EP  - 710
VL  - 171
IS  - 7
N2  - 
The report by Strom et al1 on using computerized physician order entry to prevent the coadministration of warfarin and trimethoprim-sulfamethoxazole is an excellent example of the difficulty associated with developing usable computer-assisted drug interaction screening systems. However, it failed to address an important variable that often alters the risk of an adverse outcome resulting from a drug interaction. In the study, the intervention group received a hard-stop computer alert when a patient was prescribed the 2 drugs, regardless of the order of drug administration. It appears that the alert-triggering drug was warfarin in more than 90% of the cases in both control and intervention groups. That is, warfarin was being added to the drug regimen of patients already receiving trimethoprim-sulfamethoxazole.

SN  - 0003-9926
M3  - doi: 10.1001/archinternmed.2011.109
UR  - http://dx.doi.org/10.1001/archinternmed.2011.109
ER  -