TY  - JOUR
T1  - PLatelet inhibition and cancer promotion
AU  - Goldstein MR, Mascitelli L, Pezzetta F
Y1  - 2010/11/22
N1  - 10.1001/archinternmed.2010.420
JO  - Archives of Internal Medicine
SP  - 1943
EP  - 1944
VL  - 170
IS  - 21
N2  - 
It has been shown in rodents that the platelet inhibitor, clopidogrel, increases the regulatory T-cell (Treg) pool and also increases splenic-derived endothelial progenitor cells.3 An increase in Tregs might impair host antitumor immune responses; indeed, Treg numbers in many solid tumors have correlated inversely with patient survival.4 In addition, it has become evident that endothelial progenitor cells promote tumor angiogenesis and are found more frequently in the peripheral blood and tumors of patients with more invasive disease.5

SN  - 0003-9926
M3  - doi: 10.1001/archinternmed.2010.420
UR  - http://dx.doi.org/10.1001/archinternmed.2010.420
ER  -