TY  - JOUR
T1  - Primary prevention cardiovascular disease: Better than drugs—reply
AU  - de Lorgeril M, Salen P, Rabeus M
Y1  - 2011/11/08
N1  - 10.1001/archinternmed.2010.403
JO  - Archives of Internal Medicine
SP  - 1860
EP  - 1861
VL  - 170
IS  - 20
N2  - 
Pippin proposes the adoption of a plant-based dietary pattern. We again agree that this strategy is probably better—both in terms of clinical efficiency and “side effects”—than taking a statin. Pippin backs his recommendation on the basis of the 52-nation INTERHEART study and the 2006 American Heart Association (AHA) Diet and Lifestyle Recommendations, as cited in his letter. However, evidence-based preventive medicine should primarily be based on randomized clinical trials. Neither INTERHEART (a case-control study) nor the 2006 AHA Recommendations (in which no clinical trial was cited) provide convincing evidence. This would reinforce the widespread idea that in the supposed absence of dietary trial, it is reassuring to use cholesterol-lowering drugs, despite the present statin controversy.

SN  - 0003-9926
M3  - doi: 10.1001/archinternmed.2010.403
UR  - http://dx.doi.org/10.1001/archinternmed.2010.403
ER  -