TY  - JOUR
T1  - HIgh or low doses of ppis for patients with peptic ulcer bleeding?—reply
AU  - Wang C, Ma M, Fang C, Chen S, Yen Z
Y1  - 2010/10/11
N1  - 10.1001/archinternmed.2010.354
JO  - Archives of Internal Medicine
SP  - 1699
EP  - 1700
VL  - 170
IS  - 18
N2  - 
We thank all the correspondents for their comments. Calvet et al and Lin raised concerns about the inclusion of the trials containing low-risk patients. In our subgroup analysis,1 there were 792 high-risk patients, with 401 and 391 patients in high-dose and non–high-dose groups, respectively. Although the confidence intervals were wide, no significant difference was noted in rebleeding, surgical intervention, or mortality. We still regarded it as a hint that high-dose IV PPIs might not outweigh non–high-dose PPIs.

SN  - 0003-9926
M3  - doi: 10.1001/archinternmed.2010.354
UR  - http://dx.doi.org/10.1001/archinternmed.2010.354
ER  -