TY  - JOUR
T1  - Proton pump inhibitor dose for ulcer bleeding: Is less really more?
AU  - Leontiadis GI, Howden CW
Y1  - 2010/10/11
N1  - 10.1001/archinternmed.2010.357
JO  - Archives of Internal Medicine
SP  - 1697
EP  - 1698
VL  - 170
IS  - 18
N2  - 
Although Wang et al1 stated that they conducted their meta-analysis according to the recommendations of the Cochrane Collaboration, they graded the quality of trials according to the Jadad classification. This is contrary to the recommendations of the Cochrane Collaboration, which discourages the use of quality scales. Rather, it proposes the assessment of risk of bias separately in a number of domains, with concealment of allocation being the most important criterion in determining overall trial quality.2 The Jadad scale does not take concealment of allocation into account. Moreover, had the totality of evidence been assessed using the approach recommended by the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) working group,3 it would have been graded as “low-quality evidence” rather than as “7 high-quality randomized studies.” Their literature search may have been incomplete, since recent major conference proceedings were not searched. Therefore, the results of this meta-analysis should be interpreted with great caution.

SN  - 0003-9926
M3  - doi: 10.1001/archinternmed.2010.357
UR  - http://dx.doi.org/10.1001/archinternmed.2010.357
ER  -