TY  - JOUR
T1  - LEukocyte count in vascular risk prediction
AU  - Cushman M
Y1  - 2005/03/14
N1  - 10.1001/archinte.165.5.487
JO  - Archives of Internal Medicine
SP  - 487
EP  - 488
VL  - 165
IS  - 5
N2  - 
In this issue of the ARCHIVES, Margolis and colleagues2 from the Women’s Health Initiative (WHI) Research Group report that a higher leukocyte count is associated with an increased risk of cardiovascular events and mortality among 66 261 women at 40 centers followed in the WHI Observational Study. Study participants were primarily those who inquired but were not eligible, or did not desire, to participate in the WHI clinical trials of hormone therapy and dietary intervention. The major finding of the study was that leukocyte count in the top quarter of the population distribution (>6.71 × 109 cells/L) was associated with an approximate 50% increase in the risk of myocardial infarction, stroke, total vascular disease, and total mortality, independent of other risk factors. The risk of coronary death was higher, estimated as a 230% increase. The association was similar even among women who did not self-report presence of major cardiovascular risk factors. Findings are consistent with those of other studies of leukocyte count and vascular events.3

SN  - 0003-9926
M3  - doi: 10.1001/archinte.165.5.487
UR  - http://dx.doi.org/10.1001/archinte.165.5.487
ER  -