TY  - JOUR
T1  - CLinical and economic assessment of the omeprazole test in patients with symptoms suggestive of gastroesophageal reflux disease
AU  - Fass R, Ofman JJ, Gralnek IM, et al
Y1  - 1999/10/11
N1  - 10.1001/archinte.159.18.2161
JO  - Archives of Internal Medicine
SP  - 2161
EP  - 2168
VL  - 159
IS  - 18
N2  - Objective 
    To evaluate the diagnostic accuracy of a trial of a high-dose proton pump inhibitor (the omeprazole test) in detecting gastroesophageal reflux disease (GERD) in patients with heartburn symptoms.Design 
    A randomized, double-blind, placebo-controlled, crossover trial.Patients and Setting 
    Forty-three consecutive patients with symptoms suggestive of GERD were enrolled at a Veterans Affairs medical center.Main Outcome Measures 
    Symptom response to the omeprazole test vs placebo in GERD-positive and GERD-negative patients; sensitivity, specificity, and positive and negative predictive values of the omeprazole test; and cost per correct diagnosis achieved with the omeprazole test compared with traditional diagnostic strategies.Results 
    Of 42 patients (98%) who completed the study, 35 (83%) were classified as GERD positive and 7 (17%) as GERD negative. Twenty-eight GERD-positive and 3 GERD-negative patients responded to the omeprazole test, providing a sensitivity of 80.0% (95% confidence interval, 66.7%-93.3%) and a specificity of 57.1% (95% confidence interval, 20.5%-93.8%). Economic analysis revealed that the omeprazole test saves $348 per average patient evaluated, and results in a 64% reduction in the number of upper endoscopies performed and a 53% reduction in the use of pH testing.Conclusions 
    The omeprazole test is sensitive and fairly specific for diagnosing GERD in patients with typical GERD symptoms. This strategy could result in significant cost savings and decreased use of invasive diagnostic tests.
SN  - 0003-9926
M3  - doi: 10.1001/archinte.159.18.2161
UR  - http://dx.doi.org/10.1001/archinte.159.18.2161
ER  -