TY  - JOUR
T1  - LIfe-threatening interactions between hiv-1 protease inhibitors and the illicit drugs mdma and γ-hydroxybutyrate
AU  - Harrington RD, Woodward JA, Hooton TM, Horn JR
Y1  - 1999/10/11
N1  - 10.1001/archinte.159.18.2221
JO  - Archives of Internal Medicine
SP  - 2221
EP  - 2224
VL  - 159
IS  - 18
N2  - Human immunodeficiency virus 1 (HIV-1) protease inhibitors have dramatically reduced the morbidity and mortality due to HIV-1 infection. However, most of these antiretrovirals are also potent inhibitors (and occasionally inducers) of hepatic and intestinal cytochrome P450 systems and, therefore, have the potential to alter the elimination of any substance that utilizes these metabolic pathways. We describe a patient infected with HIV-1 who was treated with ritonavir and saquinavir and then experienced a prolonged effect from a small dose of methylenedioxymetamphetamine (MDMA or ecstacy) and a nearly fatal reaction from a small dose of γ-hydroxybutyrate (GHB). We also discuss the potential for HIV-1 protease inhibitors to alter the metabolism of other abusable prescribed and illicit substances.
SN  - 0003-9926
M3  - doi: 10.1001/archinte.159.18.2221
UR  - http://dx.doi.org/10.1001/archinte.159.18.2221
ER  -