TY  - JOUR
T1  - SEcretory villous adenomas that cause depletion syndrome
AU  - Older J, Older P, Colker J, Brown R
Y1  - 1999/04/26
N1  - 10.1001/archinte.159.8.879
JO  - Archives of Internal Medicine
SP  - 879
EP  - 880
VL  - 159
IS  - 8
N2  - Secretory villous adenomas of the colon have been known to cause a depleting syndrome characterized by dehydration, prerenal azotemia, hyponatremia, hypokalemia, metabolic acidosis, obtundation, and, in severe cases, death. We describe 1 case of classic depleting syndrome and review the literature on possible mechanisms. Both cyclic adenosine monophosphate and prostaglandin E2 have been implicated as possible secretagogue compounds in the pathogenesis of this syndrome unique to the secretory variant form of villous adenomas. Indomethacin as a prostaglandin inhibitor has been used with apparent benefit in controlling the volume of rectal effluent in patients with secretory villous adenomas.
SN  - 0003-9926
M3  - doi: 10.1001/archinte.159.8.879
UR  - http://dx.doi.org/10.1001/archinte.159.8.879
ER  -