TY  - JOUR
T1  - APpropriate discard of “best” practice guidelines for acute low back pain—reply
AU  - Williams C, Maher CG, Hancock MJ, McLachlan AJ, McAuley JH, Latimer J
Y1  - 2010/06/28
N1  - 10.1001/archinternmed.2010.191
JO  - Archives of Internal Medicine
SP  - 1087
EP  - 1088
VL  - 170
IS  - 12
N2  - 
In LBP management, NSAIDs are effective, but no more than paracetamol, which has fewer adverse effects.2 Schilling et al3(p19) highlight that paracetamol “is generally considered safe, but high doses can be toxic.” Their report identifies that paracetamol-related toxic effects occur with ingestion of excessive doses, knowingly or unknowingly, or when contraindication or precautions are present. While other reports of paracetamol toxicity exist,4 these cases reveal multiple causative factors and fail to implicate paracetamol as causing significant toxic effects at recommended doses.5 Mortensen and Cullen5(p1482) state “unfortunately, the extensive literature on the subject of chronic acetaminophen toxicity includes opinions drawn from unsubstantiated case reports.”

SN  - 0003-9926
M3  - doi: 10.1001/archinternmed.2010.191
UR  - http://dx.doi.org/10.1001/archinternmed.2010.191
ER  -