TY  - JOUR
T1  - A possible epigenetic explanation for the relationship between physical activity and exceptional health among older women
AU  - Ross C
Y1  - 2010/06/28
N1  - 10.1001/archinternmed.2010.192
JO  - Archives of Internal Medicine
SP  - 1081
EP  - 1083
VL  - 170
IS  - 12
N2  - 
The epigenetic drift theory of aging holds that epimutations that develop over the course of a lifetime, resulting in the deterioration of the epigenome, contribute to the degenerative diseases of aging.2- 3 For example, epigenetic drift leading to hypomethylation of repeat elements and the hypermethylation of the promoters of tumor-suppressor genes is believed to play a role in cancer. Epigenetic mechanisms have also been proposed as a factor in Alzheimer disease, type 2 diabetes mellitus, atherosclerosis, and osteoarthritis.3

SN  - 0003-9926
M3  - doi: 10.1001/archinternmed.2010.192
UR  - http://dx.doi.org/10.1001/archinternmed.2010.192
ER  -