TY  - JOUR
T1  - Computed tomographic scans: Heart and heritable concerns also
AU  - O’Connor E
Y1  - 2010/05/10
N1  - 10.1001/archinternmed.2010.118
JO  - Archives of Internal Medicine
SP  - 835
EP  - 836
VL  - 170
IS  - 9
N2  - 
With respect to radiation-induced coronary artery disease, startling evidence exists for inferring that somatic mutations can initiate and/or accelerate formation of arteriosclerotic plaque and its rupture.2- 3 One proposed mechanism is the production of miniature tumors of mutated, dysfunctional, genomically unstable cells in arterial tissue, resulting in atheromas having fragile fibrous caps that cannot contain thrombogenic lipid pools.3 It is urgent to evaluate such evidence, because beyond doubt, low-dose CT, fluoroscopy, and nuclear medicine increase the burden of mutations accumulated in the coronary arteries.

SN  - 0003-9926
M3  - doi: 10.1001/archinternmed.2010.118
UR  - http://dx.doi.org/10.1001/archinternmed.2010.118
ER  -