TY  - JOUR
T1  - Reduction in blood pressure with statins: Results from the ucsd statin study, a randomized trial
AU  - Golomb BA, Dimsdale JE, White HL, Ritchie JB, Criqui MH
Y1  - 2008/04/14
N1  - 10.1001/archinte.168.7.721
JO  - Archives of Internal Medicine
SP  - 721
EP  - 727
VL  - 168
IS  - 7
N2  - Background 
    Some studies have suggested reductions in blood pressure (BP)with statin treatment, particularly in persons with hypertension. Randomized trial evidence is limited.Methods 
    We performed a randomized, double-blind, placebo-controlled trial with equal allocation to simvastatin, 20 mg; pravastatin sodium,40 mg; or placebo for 6 months. Nine hundred seventy-three men and women without known cardiovascular disease or diabetes mellitus, with low-density lipoprotein cholesterol screening levels of 115 to 190mg/dL, had assessment of systolic and diastolic BP (SBP and DBP, respectively). Blood pressure values were compared for placebo vs statins by intention-to-treat (ITT) analysis. Additional analyses were performed that (1) were confined to subjects with neither high baseline BP (SBP >140 mm Hg or DBP >90mm Hg) nor receiving BP medications, to exclude groups in whom BP medications or medication changes may have influenced results, and (2) separately evaluated simvastatin and pravastatin (vs placebo). The time course of BP changes after statin initiation and the effect of stopping statins on BP were examined.Results 
    Statins modestly but significantly reduced BP relative to placebo,by 2.2 mm Hg for SBP (P = .02) and 2.4mm Hg for DBP (P < .001) in ITT analysis.Blood pressure reductions ranged from 2.4 to 2.8 mm Hg for both SBP and DBP with both simvastatin and pravastatin, in those subjects with full follow-up, and without potential for influence by BP medications (ie, neither receiving nor meriting BP medications).Conclusions 
    Reductions in SBP and DBP occurred with hydrophilic and lipophilic statins and extended to normotensive subjects. These modest effects may contribute to the reduced risk of stroke and cardiovascular events reported on statins.Trial Registration 
    clinicaltrials.gov Identifier: NCT00330980
SN  - 0003-9926
M3  - doi: 10.1001/archinte.168.7.721
UR  - http://dx.doi.org/10.1001/archinte.168.7.721
ER  -