TY  - JOUR
T1  - MIgraine and heart rate variability
AU  - Perciaccante A, Fiorentini A, Valente R, Granata M, Tubani L
Y1  - 2007/11/12
N1  - 10.1001/archinte.167.20.2264-a
JO  - Archives of Internal Medicine
SP  - 2264
EP  - 2264
VL  - 167
IS  - 20
N2  - 
We report preliminary data from our study showing the presence of cardiac autonomic dysfunction in subjects with migraine. A total of 28 subjects (18 women and 10 men; mean ± SD age, 36 ± 4.2 years) with active migraine with aura, diagnosed according to criteria of the International Headache Society, were enrolled. All subjects were normotensive and normal weight and without metabolic, endocrine, cardiovascular, and renal diseases, and they were not receiving drugs that could potentially disturb cardiac autonomic activity. Twenty-five healthy subjects matched for sex, age, body mass index, and blood pressure were enrolled as a control group. In all subjects, a 24-hour electrocardiographic recording was performed, and heart rate variability was analyzed in time and frequency domain according to European Society of Cardiology guidelines.3 Spectral estimated R-R intervals were obtained from stationary regions free of ectopic beats and technical artifacts. In a time domain analysis, the standard deviation of normal R-R intervals (SDNN), correlated with total autonomic activity, was calculated. In a frequency domain analysis, low frequency–high frequency ratio, considered as an index of sympathovagal balance, was calculated. During electrocardiographic recording, all subjects had not reported migraine attacks.

SN  - 0003-9926
M3  - doi: 10.1001/archinte.167.20.2264-a
UR  - http://dx.doi.org/10.1001/archinte.167.20.2264-a
ER  -