TY  - JOUR
T1  - Metformin and vitamin b12 deficiency: Association and not causation may play a major role in cohort studies
AU  - Lev I
Y1  - 2007/04/09
N1  - 10.1001/archinte.167.7.730-a
JO  - Archives of Internal Medicine
SP  - 730
EP  - 730
VL  - 167
IS  - 7
N2  - 
In the October 9th issue of the ARCHIVES, Ting et al1 reported a dose-dependent inverse relationship between daily metformin dosage and low levels of vitamin B12. They also found a higher prevalence of vegetarians in the same group of patients with metformin-related low levels of vitamin B12 (referred to as borderline significant due to a P value of .04 and an odds ratio of 8.19 [95% confidence interval, 0.91-73.9]). The authors tried to suggest a causative relationship and recommend forgoing the annual blood examinations for vitamin B12 levels in metformin-treated patients with diabetes, since the results of such screening should be regarded as obvious.1

SN  - 0003-9926
M3  - doi: 10.1001/archinte.167.7.730-a
UR  - http://dx.doi.org/10.1001/archinte.167.7.730-a
ER  -