TY  - JOUR
T1  - Risk of diabetes and cardiovascular disease: Best to return back to the basics: comment on “long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus”
AU  - Deedwania PC
Y1  - 2010/09/27
N1  - 10.1001/archinternmed.2010.333
JO  - Archives of Internal Medicine
SP  - 1575
EP  - 1577
VL  - 170
IS  - 17
N2  - 
The article by Chao et al1 in this issue of the Archives evaluates the role of circulating biomarkers of inflammation and endothelial dysfunction in predicting the risk of type 2 DM during a 6-year follow-up period among postmenopausal women who were free of type 2 DM and CVD at the time of enrollment in the Women's Health Initiative Observational Study. In this nested case-control study of 1584 incident cases of type 2 DM and 2198 matched controls, the measurement of various plasma markers of inflammation and endothelial dysfunction did not provide significant and clinically meaningful additional independent value in identifying the risk for development of type 2 DM during follow-up. Although these findings are in contrast to those of earlier studies, some of the earlier reports were from retrospective evaluation, while others had not performed careful comparative analyses of traditional risk factors vs biomarkers.

SN  - 0003-9926
M3  - doi: 10.1001/archinternmed.2010.333
UR  - http://dx.doi.org/10.1001/archinternmed.2010.333
ER  -