TY  - JOUR
T1  - AN intensive behavioral weight loss intervention and hot flushes in women
AU  - Huang AJ, Subak LL, Wing R, et al
Y1  - 2010/07/12
N1  - 10.1001/archinternmed.2010.162
JO  - Archives of Internal Medicine
SP  - 1161
EP  - 1167
VL  - 170
IS  - 13
N2  - Background 
    Higher body mass index is associated with worse hot flushes during menopause but the effect of weight loss on flushing is unclear.Methods 
    Self-administered questionnaires were used to assess bothersome hot flushes in a 6-month randomized controlled trial of an intensive behavioral weight loss program (intervention) vs a structured health education program (control) in 338 women who were overweight or obese and had urinary incontinence. Weight, body mass index, abdominal circumference, physical activity, calorie intake, blood pressure, and physical and mental functioning were assessed at baseline and at 6 months. Repeated-measures proportional odds models examined intervention effects on bothersome hot flushes and potential mediating factors.Results 
    Approximately half of participants (n = 154) were at least slightly bothered by hot flushes at baseline. Among these women, the intervention was associated with greater improvement in bothersome flushes vs control (odds ratio [OR] for improvement by 1 Likert category, 2.25; 95% confidence interval [CI], 1.20-4.21). Reductions in weight (OR, 1.32; 95% CI, 1.08-1.61; per 5-kg decrease), body mass index (1.17; 1.05-1.30; per 1-point decrease), and abdominal circumference (1.32; 1.07-1.64; per 5-cm decrease) were each associated with improvement in flushing, but changes in physical activity, calorie intake, blood pressure, and physical and mental functioning were not related. The effect of the intervention on flushing was modestly diminished after adjustment for multiple potential mediators (OR, 1.92; 95% CI, 0.95-3.89).Conclusion 
    Among women who were overweight or obese and had bothersome hot flushes, an intensive behavioral weight loss intervention resulted in improvement in flushing relative to control.Trial Registration 
    clinicaltrials.gov Identifier: NCT00091988
SN  - 0003-9926
M3  - doi: 10.1001/archinternmed.2010.162
UR  - http://dx.doi.org/10.1001/archinternmed.2010.162
ER  -