TY  - JOUR
T1  - Eosinophilia and diseases: Clinical revision of 1862 cases
AU  - Lombardi C, Passalacqua G
Y1  - 2003/06/09
N1  - 10.1001/archinte.163.11.1371-a
JO  - Archives of Internal Medicine
SP  - 1371
EP  - 1373
VL  - 163
IS  - 11
N2  - 
Eosinophils were first described in 1879 by Paul Ehrlich, based on their staining behavior. Eosinophils are a subpopulation of leukocytes, originating in the bone marrow from a CD34+ precursor. They circulate in peripheral blood, where they represent 2% to 3% of total white cells, and have a half-life of approximately 8 to 18 hours. Nevertheless, once recruited in peripheral tissues by specific cytokines, eosinophils can survive for days or weeks as resident cells. Eosinophils possess a powerful enzymatic machinery (eosinophil-derived neurotoxin, eosinophil cationic protein, and major basic protein) not shared with other types of granulocytes.1

SN  - 0003-9926
M3  - doi: 10.1001/archinte.163.11.1371-a
UR  - http://dx.doi.org/10.1001/archinte.163.11.1371-a
ER  -