TY  - JOUR
T1  - The incremental nature of clinical research: Comment on “the association of aspirin use with age-related macular degeneration”
AU  - Covinsky KE
Y1  - 2013/02/25
N1  - 10.1001/jamainternmed.2013.2790
JO  - JAMA Internal Medicine
SP  - 266
EP  - 266
VL  - 173
IS  - 4
N2  - 
The eloquent Invited Commentary by Kaul and Diamond illustrates the great care that must be taken before concluding that an association described in an observational study truly represents a cause-effect relationship. In our discussion of the article by Liew and colleagues, the editors believed that it provided useful incremental data about an important condition. However, as with many good studies, the data are not definitive enough to suggest changes in clinical practice. Rather, we hope the study galvanizes more research on the relationship between aspirin and macular degeneration. For example, ASPREE (Aspirin in Reducing Events in the Elderly), a large international, randomized controlled trial on the effect of aspirin on cardiovascular outcomes and dementia in elderly persons, hopefully will consider rigorously assessing for macular degeneration.

SN  - 2168-6106
M3  - doi: 10.1001/jamainternmed.2013.2790
UR  - http://dx.doi.org/10.1001/jamainternmed.2013.2790
ER  -