TY  - JOUR
T1  - Misconstrued intentions: Setting the record straight
AU  - Novack V, Cohen DJ, Cutlip DE
Y1  - 2012/10/08
N1  - 10.1001/archinternmed.2012.3752
JO  - Archives of Internal Medicine
SP  - 1425
EP  - 1427
VL  - 172
IS  - 18
N2  - 
In particular, we were disappointed to discover that the objective and major conclusions of our study were misinterpreted within the commentary. As clearly outlined in the article, our aim was to compare the effects of a troponin- or creatine kinase–MB (CKMB)-based definition of periprocedural myocardial infarction (MI) on event frequency and the association of these events with 1-year mortality. Our results indicated a significant difference in sensitivity such that the frequency of troponin MI (troponin values >3 times the upper limit of normal [ULN]) was more than 3-fold higher than CKMB MI (CKMB values >3 times the ULN). Moreover, although elevations of both troponin and CKMB levels were prognostically important, a comparable association between biomarker elevation and 1-year mortality was observed at much higher relative elevations of troponin than CKMB. Our article did not suggest a preference for CKMB or state that CKMB assays were more reliable based on longer-term use.

SN  - 0003-9926
M3  - doi: 10.1001/archinternmed.2012.3752
UR  - http://dx.doi.org/10.1001/archinternmed.2012.3752
ER  -