TY - JOUR T1 - Implementing high-value, cost-conscious diabetes mellitus care through the use of low-cost medications and less-intensive glycemic control target: Comment on "variation in use of high-cost diabetes mellitus medications in the va healthcare system" AU - Wilt TJ, Qaseem A Y1 - 2012/11/12 N1 - 10.1001/2013.jamainternmed.203 JO - Archives of Internal Medicine SP - 1610 EP - 1611 VL - 172 IS - 20 N2 - Type 2 diabetes mellitus (DM) is a leading cause of morbidity and mortality, affecting nearly 26 million people and costing $174 billion in the United States.1 Monotherapy with oral agents lower hemoglobin A1c (HbA1c) levels an average of 1% of total hemoglobin. Combination therapy with a second oral medication or insulin leads to an additional 1% to 2% reduction. (To convert HbA1cto a proportion of total hemoglobin, multiply by 0.01.) Most people with type 2 DM will receive more than 1 class of medication: 14% take both insulin and oral medications, and 58% take multiple oral DM medications.1 SN - 0003-9926 M3 - doi: 10.1001/2013.jamainternmed.203 UR - http://dx.doi.org/10.1001/2013.jamainternmed.203 ER -