TY - JOUR T1 - INvited commentary—genetic prediction for common diseases AU - Ioannidis JA Y1 - 2012/05/14 N1 - 10.1001/archinternmed.2012.931 JO - Archives of Internal Medicine SP - 744 EP - 746 VL - 172 IS - 9 N2 - A major promise of human genetics has been the use of genetic information to predict the risk of common diseases in order to prevent and treat these conditions more effectively. Most common diseases have a complex etiology, and genes are expected to explain much of their risk. However, even though PubMed already retrieves more than 2 million articles with “gene OR genetic” (n = 2 015 109 as of February 10, 2011) and half (n = 1 040 434) are tagged as “Human,” there are formidable difficulties in materializing this promise.1 SN - 0003-9926 M3 - doi: 10.1001/archinternmed.2012.931 UR - http://dx.doi.org/10.1001/archinternmed.2012.931 ER -