TY  - JOUR
T1  - From association to mechanism: Comment on “antipsychotic use and myocardial infarction in older patients with treated dementia”
AU  - Gill SS, MD, MSc, Seitz DP, MD
Y1  - 2012/04/23
N1  - 10.1001/archinternmed.2012.682
JO  - Archives of Internal Medicine
SP  - 654
EP  - 655
VL  - 172
IS  - 8
N2  - 
Antipsychotic medications are prescribed routinely to manage various neuropsychiatric symptoms in older adults with dementia. In recent years, atypical antipsychotics (eg, risperidone, olanzapine, and quetiapine fumarate) have essentially replaced older typical agents, such as haloperidol, in this setting. Although widespread use of antipsychotics to treat older persons with dementia persists, there has been increasing recognition of the serious adverse effects associated with these medications. In 2005, evidence emerged that antipsychotic treatment increased overall mortality among older adults with dementia.1 The increased risk for death associated with antipsychotic use has raised several important questions, and among them is the question of how exposure to these drugs leads to death.

SN  - 0003-9926
M3  - doi: 10.1001/archinternmed.2012.682
UR  - http://dx.doi.org/10.1001/archinternmed.2012.682
ER  -