TY  - JOUR
T1  - Supplemental oxygen therapy in medical emergencies: More harm than benefit?
AU  - Cornet AD, Kooter AJ, Peters ML, Smulders YM
Y1  - 2012/02/13
N1  - 10.1001/archinternmed.2011.624
JO  - Archives of Internal Medicine
SP  - 289
EP  - 290
VL  - 172
IS  - 3
N2  - 
Over the decades, however, potential detrimental effects of supplemental oxygen appear to have been ignored. Many clinicians are unaware of the variety of preclinical studies that have been executed, showing that hyperoxia causes both coronary and systemic vasoconstriction, resulting in deterioration of several important (hemodynamic) parameters (Table). The prime candidate mechanism for these unintended effects is believed to be the formation of reactive oxygen species. In this Research Letter, we draw attention to the collective clinical evidence, which argues against the routine use of high-dose oxygen. Awaiting more thorough studies, we strongly recommend a policy of careful, titrated oxygen supplementation.

SN  - 0003-9926
M3  - doi: 10.1001/archinternmed.2011.624
UR  - http://dx.doi.org/10.1001/archinternmed.2011.624
ER  -