TY  - JOUR
T1  - PHysical activity, vascular health, and cognitive impairment—reply
AU  - Middleton LE
Y1  - 2012/01/09
N1  - 10.1001/archinternmed.2011.616
JO  - Archives of Internal Medicine
SP  - 83
EP  - 84
VL  - 172
IS  - 1
N2  - 
My colleagues and I thank Dr Smith for his interest in our article.1 Dr Smith raises the possibility that cardiorespiratory fitness may mediate the relationship between activity energy expenditure (AEE) and cognitive impairment. Though physical activity is 1 predictor, AEE itself is only weekly associated with cardiorespiratory fitness.2 As a result, other mechanisms such as alteration in brain-derived neurotrophic factor levels and improvement of vascular function are likely to contribute to the relationship.3

SN  - 0003-9926
M3  - doi: 10.1001/archinternmed.2011.616
UR  - http://dx.doi.org/10.1001/archinternmed.2011.616
ER  -