TY - JOUR T1 - OPtimal anticoagulation therapy in patients with valvular heart disease or atrial fibrillation—reply AU - Torn M, Rosendaal FR Y1 - 2009/11/23 N1 - 10.1001/archinternmed.2009.421 JO - Archives of Internal Medicine SP - 2033 EP - 2033 VL - 169 IS - 21 N2 - With McLeod and Gersh, we believe that, in general, myocardial infarction is not merely an embolic event, but it is thrombotic, and hence “thromboembolic.” Clot formation plays an important role in myocardial infarction, even in severe atherosclerosis. Although not widely used, vitamin K antagonists are effective in preventing myocardial infarction and may well be superior to antiplatelet agents.2 Therefore, we included myocardial infarction as a thromboembolic end point. SN - 0003-9926 M3 - doi: 10.1001/archinternmed.2009.421 UR - http://dx.doi.org/10.1001/archinternmed.2009.421 ER -