TY  - JOUR
T1  - FLuconazole use as an important risk factor in the emergence of fluconazole-resistant candida glabrata fungemia
AU  - Tumbarello M, Posteraro B, Trecarichi EM, Sanguinetti M
Y1  - 2009/08/10
N1  - 10.1001/archinternmed.2009.243
JO  - Archives of Internal Medicine
SP  - 1444
EP  - 1445
VL  - 169
IS  - 15
N2  - 
Although with a smaller number of patients, a similar investigation with the same study design was previously carried out by our group.2 In accordance with Lee et al,1 our study had identified prior fluconazole exposure as the most important predisposing factor for subsequent C glabrata fungemia due to a less-susceptible isolate. We found that diabetes mellitus and central venous catheters were other independent risk factors for fungemia caused by a fluconazole–less-susceptible isolate, whereas previous surgery and central venous catheterization were independent risk factors for fungemia due to a susceptible isolate; unfortunately, these variables do not appear to have been analyzed by Lee et al.1 With regard to the antibiotic use, we did not find a significant association between fluconazole-resistant C glabrata fungemia and the use of any antibiotics; it was not possible to assess the impact of linezolid use because this drug was not largely used in Italy during the first years of our study. We found that cephalosporin (and glycopeptide or aminoglycoside) use was significantly associated with fluconazole-susceptible C glabrata fungemia, but in univariate analysis only.

SN  - 0003-9926
M3  - doi: 10.1001/archinternmed.2009.243
UR  - http://dx.doi.org/10.1001/archinternmed.2009.243
ER  -