TY  - JOUR
T1  - ACid suppressive therapy in noncritically ill patients
AU  - Barletta JF, El-Ibiary SY
Y1  - 2011/11/14
N1  - 10.1001/archinternmed.2011.513
JO  - Archives of Internal Medicine
SP  - 1862
EP  - 1864
VL  - 171
IS  - 20
N2  - 
We read with great interest the article by Herzig et al1 describing acid-suppressive therapy and the risk for nosocomial gastrointestinal tract (GI) bleeding. The authors have reported the incidence of clinically significant bleeding (which we believe is the most relevant end point) to be extremely low (0.22%), resulting in a number needed to treat to prevent 1 episode of bleeding of 834. This study validates previous statements that acid-suppressive therapy should not routinely be administered to noncritically ill patients or patients who lack major risk factors for stress-related clinically significant bleeding.2

SN  - 0003-9926
M3  - doi: 10.1001/archinternmed.2011.513
UR  - http://dx.doi.org/10.1001/archinternmed.2011.513
ER  -