TY - JOUR T1 - Body weight in early and mid-adulthood in relation to subsequent coronary heart disease mortality: 80-year follow-up in the harvard alumni study AU - Gray L, Lee I, Sesso HD, Batty G Y1 - 2011/10/24 N1 - 10.1001/archinternmed.2011.486 JO - Archives of Internal Medicine SP - 1768 EP - 1770 VL - 171 IS - 19 N2 - In the very few studies conducted,1- 4 obesity in young adults is generally associated with an increased risk of future coronary heart disease (CHD). However, data interpretation is complicated by methodological limitations, which include small study size; a paucity of studies examining the impact of confounding factors; and unexplored mechanisms, including the essentially unknown contributions of early vs later body weight on CHD risk,5- 6 which has implications for weight control interventions. In the largest and best characterized study to date, to our knowledge, we directly address these shortcoming. SN - 0003-9926 M3 - doi: 10.1001/archinternmed.2011.486 UR - http://dx.doi.org/10.1001/archinternmed.2011.486 ER -