RT Journal A1 HOISHOLT AW T1 CUrrent ideas on aphasia with studies of an interesting case JF Archives of Internal Medicine JO Archives of Internal Medicine YR 1909 FD June 1 VO III IS 5 SP 451 OP 466 DO 10.1001/archinte.1909.00050160082006 UL http://dx.doi.org/10.1001/archinte.1909.00050160082006 AB HISTORY OF THE THEORY OF APHASIA  The first observations on the subject of aphasia were made by Bouillaud in 1825 and by Dax, senior, in 1836, but the fundamental understanding of speech-defects and of their origin in lesions of the brain-cortex is due to the studies of Broca, who formulated the results of his researches in a declaration made before the Academy of Medicine of Paris in 1861, in which he claimed to have shown that the center of speech is located in the third frontal convolution of the left hemisphere. Since Broca, in the early seventies, finally succeeded in overcoming all opposition to his doctrine, establishing that the location of the speech center in the right hemisphere is found only in left-handed persons, the cerebral location of the center of speech has been moved more and more laterally and posteriorly in the cortex. It is especially