RT Journal
A1 Cutler JA, Allender P, Cook N, Follman D, Hennekens CH, Whelton PK
T1 SAlt, blood pressure, and cointervention-reply
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1997
FD December 8
VO 157
IS 22
SP 2667
OP 2667
DO 10.1001/archinte.1997.00440430148027
UL http://dx.doi.org/10.1001/archinte.1997.00440430148027
AB Despite previous correspondence,1-3 Logan continues, erroneously, to equate the blood pressure effects estimated in his meta-analysis per 100 mmol/d change in sodium excretion4 with the blood pressure effects observed in TOHP II for 24 to 40 mmol/d change in sodium.5 The TOHP II result in fact represents 2.5 to 4.0 times the 1.0—mm Hg effect from the meta-analysis, if one assumes a linear relationship through that range. He further expresses surprise at the range of blood pressure responses, without noting that these occurred over different follow-up periods during which adherence (group differences in sodium excretion) diminished somewhat and may also have become increasingly less well measured. Since all these issues were discussed in the article, we are surprised at his surprise.Logan then criticizes the main results of TOHP II, as well those of a recent meta-analysis of sodium reduction trials published subsequent to his own,6