RT Journal
A1 Wood CA
T1 Quinolone resistance: A practical perspective
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1993
FD January 11
VO 153
IS 1
SP 120
OP 121
DO 10.1001/archinte.1993.00410010140015
UL http://dx.doi.org/10.1001/archinte.1993.00410010140015
AB The recent letter by Fish et al1 discusses concern over the development of resistance to the fluoroquinolone antibiotics, especially in Staphylococcus aureus and Pseudomonas aeruginosa.2,3 They suggest that resistance to fluoroquinolones should be reexamined in comparison with rates of emergence of resistance to other classes of antibiotics. The authors cite two references4,5 that support the concepts that the incidence of resistance to the quinolones, and the development of resistance during fluoroquinolone therapy, occurs at approximately the same frequency as with β-lactam antibiotics and aminoglycosides. They conclude that quinolone resistance is not unique but is a problem common to all antibiotics. The authors acknowledge the tremendous explosion in the use of ciprofloxacin, and they concede that this usage is likely related to the reports of increasing resistance. The letter ends by suggesting that "the notoriety that the quinolones are gaining with regard to development of resistance is