RT Journal
A1 Crussell-Porter LL, Rindone JP, Ford MA, Jaskar DW
T1 LOw-dose fluconazole therapy potentiates the hypoprothrombinemic response of warfarin sodium
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1993
FD January 11
VO 153
IS 1
SP 102
OP 104
DO 10.1001/archinte.1993.00410010124012
UL http://dx.doi.org/10.1001/archinte.1993.00410010124012
AB Background: 
    Fluconazole has been reported to interact with many medications. This study examined the effect of low-dose fluconazole therapy on the hypoprothrombinemic response of warfarin sodium in patients.Methods: 
    Patients receiving low-intensity anticoagulation therapy with warfarin were recruited. All patients were taking stable doses of warfarin and had two baseline prothrombin times (PTs) within 10% of each other. Each patient received 100 mg of fluconazole daily for 7 days. Prothrombin times were measured on days 2,5, and 8 during fluconazole administration.Results: 
    All patients had a progressive increase in PTs. Mean (±SD) of PTs increased from 15.8±1 seconds before the administration of fluconazole to 18.9±1.9 seconds on day 5 and 21.9±2.2 seconds on day 8. Fluconazole therapy was stopped early in three patients due to high PTs. The largest change in PT was 9.7 seconds. No bleeding was noted during the study.Conclusion: Fluconazole predictably potentiates the hypoprothrombinemic response of warfarin. Prothrombin times must be monitored when fluconazole is administered to patients taking warfarin.(Arch Intern Med. 1993;153:102-104)