RT Journal
A1 Hodgson MJ, Heyl AE, Van Thiel DH
T1 LIver disease associated with exposure to 1,1,1 -trichloroethane
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1989
FD August 1
VO 149
IS 8
SP 1793
OP 1798
DO 10.1001/archinte.1989.00390080065015
UL http://dx.doi.org/10.1001/archinte.1989.00390080065015
AB • 1,1,1-Trichloroethane is a halogenated hydrocarbon solvent commonly used in industry because of its supposed lack of hepatotoxicity. Nonetheless, animal studies performed by several independent groups have shown the solvent to induce fat deposition, vacuolar degeneration, and centrilobular necrosis, changes similar to those seen after exposure to carbon tetrachloride, albeit of a much reduced magnitude, in animals exposed to the agent. Four patients with fatty liver disease whose work entailed substantial exposure to this agent were seen at the University of Pittsburgh (Pa). Based on this clinical experience, we believe that 1,1,1-trichloroethane should be reconsidered as an agent with potential hepatotoxicity in man.(Arch Intern Med. 1989;149:1793-1798)