RT Journal A1 Schleifer SJ, Macari-Hinson MM T1 THe nature and course of depression following myocardial infarction JF Archives of Internal Medicine JO Archives of Internal Medicine YR 1989 FD August 1 VO 149 IS 8 SP 1785 OP 1789 DO 10.1001/archinte.1989.00390080059014 UL http://dx.doi.org/10.1001/archinte.1989.00390080059014 AB • Two hundred eighty-three patients admitted to cardiac care units for myocardial infarction at two urban teaching hospitals were interviewed 8 to 10 days after infarction and 171 were reinterviewed 3 to 4 months later. Initially, 45% met diagnostic criteria for minor or major depression, including 18% with major depressive syndromes. Depression was not associated with the severity of cardiac illness but was associated with the presence of noncardiac medical illnesses. Three to 4 months after infarction, 33% of patients met criteria for minor or major depression. The large majority of patients who initially met criteria for major but not minor depression showed evidence of depression at 3 months and most patients with major depression had not returned to work by 3 months. Treatment of major depressive syndromes after myocardial infarction may reduce chronicity and disability, while minor depressive syndromes may be similar to normal grief and tend to be self-limited.(Arch Intern Med. 1989;149:1785-1789)