RT Journal
A1 WOLF PL
T1 THe importance of a2-antiplasmin in the defibrination syndrome
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1989
FD August 1
VO 149
IS 8
SP 1724
OP 1725
DO 10.1001/archinte.1989.00390080010002
UL http://dx.doi.org/10.1001/archinte.1989.00390080010002
AB Two coagulation abnormalities may result in a marked decrease in plasma fibrinogen caused by prominent defibrination. The two conditions that cause defibrination with a bleeding diathesis are disseminated intravascular coagulation (DIC) and primary fibrinogenolysis (PF).1Various conditions may be associated with DIC. These include serious infections; complications of pregnancy, such as abruptio placentae or toxemia (PIH); malignancy, such as carcinomas or acute promyelocytic leukemia; marked tissue injury, such as brain injury and incompatible hemolytic transfusion reaction; and venomous snakebite.The cause of PF differs from DIC. Primary fibrinogenolysis is associated with cirrhosis, since the liver normally removes plasminogen activator from the circulation. Other conditions associated with PF are extensive cardiovascular or pulmonary surgery and metastatic carcinoma of the prostate, releasing plasminogen activator into the circulation. The recent utilization of tissue plasminogen activator to cause thrombolysis of coronary artery and cerebral artery thrombi causes local fibrinogenolysis.The laboratory parameters used