RT Journal
A1 Doolittle GC, Simpson KM, Lindsley HB
T1 MEthotrexate-associated, early-onset pancytopenia in rheumatoid arthritis
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1989
FD June 1
VO 149
IS 6
SP 1430
OP 1431
DO 10.1001/archinte.1989.00390060140032
UL http://dx.doi.org/10.1001/archinte.1989.00390060140032
AB • A patient with rheumatoid arthritis presented with pancytopenia 3 weeks after initiation of low-dose methotrexate administered orally. She had minimal renal insufficiency and hypoalbuminemia prior to initiation of methotrexate therapy, and had received a nonsteroidal anti-inflammatory drug concurrently. Bone marrow recovery occurred within 3 weeks. Patients receiving low-dose methotrexate therapy for rheumatoid arthritis require early monitoring for bone marrow injury, especially those who have risk factors for possible methotrexate toxicity.(Arch Intern Med. 1989;149:1430-1431)