RT Journal
A1 Lisker-Melman M, Hoofnagle JH
T1 PHenytoin hepatotoxicity masked by corticosteroids
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1989
FD May 1
VO 149
IS 5
SP 1196
OP 1197
DO 10.1001/archinte.1989.00390050148032
UL http://dx.doi.org/10.1001/archinte.1989.00390050148032
AB • The association of phenytoin and liver toxicity is well documented. This article describes a patient who underwent a trans sphenoidal resection of a pituitary tumor who developed phenytoin-induced hepatotoxicity that was masked by the simultaneous administration of corticosteroids for treatment of cerebral edema. In a patient receiving both medications, the systemic manifestations of the hypersensitivity to phenytoin may go unrecognized, leading to delayed identification of a potentially lethal complication of this commonly prescribed anticonvulsant.(Arch Intern Med. 1989;149:1196-1197)