RT Journal
A1 Woolf AD, Campion GV, Chishick A, et al
T1 CLinical manifestations of human parvovirus b19 in adults
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 1989
FD May 1
VO 149
IS 5
SP 1153
OP 1156
DO 10.1001/archinte.1989.00390050111022
UL http://dx.doi.org/10.1001/archinte.1989.00390050111022
AB • Human parvovirus B19 has been associated with various clinical effects in a number of uncontrolled reports. To define the usual manifestations of B19 infection in adults and the factors that influence them we present a clinicoepidemiological study of an outbreak of B19 infection centered on a junior school. Four hundred fifty-three of 475 adults in this community were interviewed and blood was obtained for serological diagnosis. Fifty-four cases of recent infection were identified and were HLA typed. Fourteen of the cases were asymptomatic; 32 had an influenzalike illness; 23 a rash; and 26 an acute-onset polyarthropathy that was more common in women and lasted for up to 7 months. HLA-A, -B, and -C antigen frequencies were similar to a local control population and showed no association with symptoms except that HLA-DR1 was absent in those with persistent arthropathy.(Arch Intern Med. 1989;149:1153-1156)